Vitamin D, B Vitamins and Mood
Vitamin D and B vitamins come up often in anxiety and mood threads, but in a hand-checked sample most owner comments were about correcting a low blood level or general health rather than calm or mood. Over half have no clear sentiment. We keep pages for them as background and leave them out of rankings.
| Supplement | Score | Owner comments | Rated | Status |
|---|---|---|---|---|
| Vitamin D3 | 3.5 | 183 | 83 | Background page |
| B-complex / B vitamins | 3.1 | 139 | 68 | Background page |
| Omega-3 / fish oil (EPA/DHA) | 3.2 | 66 | 27 | Ranked |
| Methylfolate (L-methylfolate) | 3.2 | 15 | 11 | Ranked |
Vitamin D
A blood test is the usual way to know whether your vitamin D is low; the adult upper limit is 4,000 IU a day.[NIH Office of Dietary Supplements] Meta-analyses of vitamin D and depressive symptoms report mixed results.[PubMed][PubMed]
B vitamins
A 2019 meta-analysis linked B-vitamin supplements with lower stress ratings, with less clear effects on mood.[PubMed] Long-term vitamin B6 above 100 mg a day can cause nerve damage.[NIH Office of Dietary Supplements]
Omega-3 and methylfolate
We do rank omega-3 and methylfolate, because their owner comments are more often about mood. Both have been studied in depression, mostly as add-ons.[PubMed][PubMed]
You can also compare all rated mood supplements on one page. Our stress supplement shortlists group top-rated options by what people report. A step-by-step guide to picking a calming supplement covers medicines and dosing.