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Supplements for PMS and PMDD Mood Symptoms: What Reddit Users Report

This ranking reflects what people who mention PMS or PMDD mood symptoms report in Reddit comments: 19 owner comments, ranked by a context rating that shrinks small samples toward the average. It is not a recommendation to try any of them. Persistent or severe symptoms need a doctor's assessment. Vitamin D and B vitamins are left out as background pages.

#SupplementContext ratingRated comments herePositiveNegativeOverall score
1NAC (N-acetylcysteine)3.73203.2
2Magnesium glycinate3.53204.0
3Magnesium (form not stated)3.43214.1

In their words

3/5 Feeling flat or numbMood

“Turns out all signs point to the long-term NAC use from my understanding (albeit the long period of Accutane probably had some mild effect on me as well).”

owner comment via r/Nootropics · 2026-05-06 · 2 upvotes
4/5 Calming effectSleep depth

“Yes, I've found taking a short break can be a good way to notice whether magnesium glycinate is actually supporting you.”

owner comment via r/Supplements · 2026-07-09 · 2 upvotes
4/5

“I used to take Life Extension magnesium but stopped after like 2 weeks.”

owner comment via r/sleep · 2026-06-17 · 2 upvotes

Mixed and negative reports

2/5

“I take magnesium regularly for my period cramps.”

owner comment via r/Anxiety · 2026-09-03 · 5 upvotes

Before you try anything