Medical disclaimer: CalmVerdict summarizes what people say about supplements on Reddit. It is not medical advice, and nothing here is meant to diagnose, treat, cure, or prevent any disease. These statements have not been evaluated by the Food and Drug Administration. Talk to your doctor or pharmacist before starting a supplement, especially if you take an antidepressant or other medicine, are pregnant, or have a medical condition. Do not stop or change prescribed medicine on your own. If you are in crisis or thinking about suicide, call or text 988 (US) or your local emergency number. Full disclaimer.

5-HTP vs L-tryptophan

On Reddit, owners rate L-tryptophan higher overall (3.5 vs 3.5). Scores summarize self-reported experiences and are not evidence that either will work for you.

5-HTPL-tryptophan
Typecapsulescapsules
CalmVerdict score3.53.5
Owner sentiment3.74.0
Recommendations1.01.0
Tolerability4.54.3
Owner comments216
Rated comments96
Unwanted effects reported11%17%
Top praiseDose & timing, Feeling flat or numbMood, Dose & timing
Top complaintsSide effectsSide effects

By concern

Context5-HTPL-tryptophan
Anxiety & worry3 of 4 positiveToo few comments
Low mood4 of 10 positive4 of 4 positive

What owners say about 5-HTP

4/5

“I took about that, 900 mg 5-HTP per day, for a while.”

owner comment via r/Supplements · 2026-08-07 · 2 upvotes
4/5

“I dislike 5 htp, it will likely just stay in the gut.”

owner comment via r/Nootropics · 2026-06-06 · 1 upvotes
4/5

“I've been thinking of trying 5htp...for anxiety and help with binge eating tendencies, but I see so much conflicting information.”

owner comment via r/Nootropics · 2026-09-02 · 1 upvotes

Full 5-HTP page →

What owners say about L-tryptophan

4/5 MoodTakes time

“Ive been taking l-theanine and l-tryptophan and its made a huge impact on my mental health.”

owner comment via r/Supplements · 2026-10-03 · 2 upvotes
4/5 Mood

“I was taking Tryptophan for sleep, and it worked fantastic for that”

owner comment via r/Supplements · 2026-06-05 · 1 upvotes
5/5

“For me it has been L tryptophan. Has been a game changer for me I take 440mg 3 times a day and it has been great. I also have ocd and thats all I take.”

owner comment via r/Supplements · 2026-08-07 · 1 upvotes

Full L-tryptophan page →

Talk to a doctor or pharmacist before switching or combining supplements, particularly if you take other medicines.