Medical disclaimer: CalmVerdict summarizes what people say about supplements on Reddit. It is not medical advice, and nothing here is meant to diagnose, treat, cure, or prevent any disease. These statements have not been evaluated by the Food and Drug Administration. Talk to your doctor or pharmacist before starting a supplement, especially if you take an antidepressant or other medicine, are pregnant, or have a medical condition. Do not stop or change prescribed medicine on your own. If you are in crisis or thinking about suicide, call or text 988 (US) or your local emergency number. Full disclaimer.

Question · Anxiety & worry

Does magnesium glycinate help with anxiety?

Reports are mixed, going by Reddit owner reports: 43 of 75 rated comments from people who describe anxiety or constant worry describe a good experience with Magnesium glycinate, and 23 describe a poor one. That is self-reported experience, not proof that it works, and results vary from person to person.

Magnesium glycinate, Anxiety & worry	Owner comments
Rated comments in this context	75
Positive	43 (57%)
Negative	23 (31%)
Describe an unwanted effect	12
Context rating (small samples pulled to the average)	3.2

Magnesium glycinate overall: 4.0 from 370 owner comments in Reddit anxiety, stress and supplement communities, May 2026 to October 2026.

What the research says

Magnesium glycinate (bisglycinate) is magnesium bound to the amino acid glycine.^{[NIH Office of Dietary Supplements]}
Absorption studies have compared organic forms such as diglycinate with magnesium oxide.^[PubMed]^[PubMed]

Safety

The NIH upper limit for magnesium from supplements is 350 mg a day for adults; higher doses commonly cause diarrhea, nausea and abdominal cramping.^{[NIH Office of Dietary Supplements]}
Magnesium can reduce the absorption of some antibiotics (tetracyclines, quinolones) and bisphosphonates, so the NIH advises spacing the doses apart.^{[NIH Office of Dietary Supplements]}

Good experiences

4/5 GrogginessSide effects
“For example, magnesium bisglycinate works wonders for my girlfriend's anxiety, whereas when I have it (and I've tried multiple times) I get an immense grogginess and depression the next day.”

owner comment via r/Supplements · 2026-06-05 · 12 upvotes

5/5
“Magnesium glycinate helped me a lot with the physical anxiety symptoms, stopped that constant chest tightness I used to get.”

owner comment via r/Supplements · 2026-09-08 · 12 upvotes

4/5 Taste & form
“But that plus my 2 daily magnesium Glycinate pills”

owner comment via r/Anxiety · 2026-09-03 · 10 upvotes

Poor experiences

2/5
“ngl it did nothing for me personally, took glycinate for like 6 weeks and couldn't honestly tell a before/after difference.”

owner comment via r/sleep · 2026-07-26 · 9 upvotes

1/5
“Mag gly gives me terrible anxiety upon waking.”

owner comment via r/Nootropics · 2026-05-06 · 6 upvotes

How reports compare in other contexts

Context	Rated comments	Positive	Negative
Everyday stress	39	33	4
Low mood	24	13	10
Panic attacks	12	8	2
Physical tension	8	6	2

More on Magnesium glycinate

Talk to a doctor about new, severe or lasting symptoms, and to a pharmacist before combining supplements with medicines.